Lessons from limk1 enzymology and their impact on inhibitor design

HIGHLIGHTS

• who: Eidarus Salah and collaborators from the Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford , FZ, UK. have published the research work: Lessons from LIMK1 enzymology and their impact on inhibitor design, in the Journal: (JOURNAL)
• what: The authors show that LIMK1 robustly phosphorylates both serine and tyrosine residues, establishing LIMK1 as a dual-specificity kinase. The authors propose a new rock-and-poke mechanism for substrate phosphorylation by the LIM kinases.
• how: Data were analysed with the MxPro software.
• future: It may be interesting in . . .
  

   

  

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