Multilevel structure-activity profiling reveals multiple green tea compound families that each modulate ubiquitin-activating enzyme and ubiquitination by a distinct mechanism

HIGHLIGHTS

  • who: Gabriel Fenteany from the of the Hungarian Academy of Sciences, Szeged, Hungary Department of Medical Chemistry, University of have published the Article: Multilevel structure-activity profiling reveals multiple green tea compound families that each modulate ubiquitin-activating enzyme and ubiquitination by a distinct mechanism, in the Journal: Scientific Reports Scientific Reports of 14/08/2019
  • what: The authors seek to identify and exploit new small-molecule modulators of the PCNA ubiquitination cascade as potential therapeutics and research tools.
  • how: The authors designed and implemented a quantitative high-throughput assay for PCNA ubiq . . .

     

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