HIGHLIGHTS
- who: Antonio J. Pagán from the University of Cambridge, Cambridge , QH, UK have published the Article: Myeloid Growth Factors Promote Resistance to Mycobacterial Infection by Curtailing Granuloma Necrosis through Macrophage Replenishment, in the Journal: (JOURNAL)
- what: This work provides a unifying mechanistic explanation for both phenotypes by implicating the reduced macrophage demand of the mutant in both. The experiments show that increasing the myeloid pool even after granulomas have formed can reduce their necrosis.
- how: EXPERIMENTAL PROCEDURES Bacterial Strains M. marinum M strain (ATCC #BAA-535) and its mutant derivatives DESX-1 . . .
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