Improved pharmacokinetics of tenofovir ester prodrugs strengthened the inhibition of hbv replication and the rebalance of hepatocellular metabolism in preclinical models

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  • who: August and colleagues from the United States University at Buffalo, United States have published the paper: Improved pharmacokinetics of tenofovir ester prodrugs strengthened the inhibition of HBV replication and the rebalance of hepatocellular metabolism in preclinical models, in the Journal: (JOURNAL)
  • what: A total of 680 lipids, including 283 triacylglycerols (TAGs), 39 diacylglycerols (DAGs), 3 monoglycerides (MAGs), 350 lipoids and 5 free fatty_acids (FFAs), were detected in the method , and PCA analysis indicated that these prodrugs were more potently rebalanced in lipoids than in total lipids, so the subsequent analysis focused on lipoids . The . . .

     

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