Small molecule-mediated allosteric activation of the base excision repair enzyme 8-oxoguanine dna glycosylase and its impact on mitochondrial function

HIGHLIGHTS

• who: Gaochao Tian from the Division University of have published the research work: Small molecule-mediated allosteric activation of the base excision repair enzyme 8-oxoguanine DNA glycosylase and its impact on mitochondrial function, in the Journal: Scientific Reports Scientific Reports
• what: The authors examined the time- and concentration-dependent effects of PQ on ROS production. This studies demonstrate that activation of OGG1 | Vol:.(1234567890) 12:14685 | can be obtained by 9-deazaGua.
• how: These data indicated that the activation efficiency of these compounds which were structurally distinct from product analogs was as . . .
  

   

  

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