HIGHLIGHTS
- who: Changes et al. from the (UNIVERSITY) have published the Article: Received 08/08/2022 Review began 08/13/2022 Review ended 08/28/2022 Published 08/29/2022, in the Journal: (JOURNAL) of August/29,/2022
- what: Moraes Filho states that functional heartburn, non-adherence to therapy, insufficient instructions, variations in the genetic constitution, alkaline gastroesophageal reflux, autoimmune disorders, eosinophilic esophagitis, and wrong diagnosis are the main reasons for refractory GERD .
- future: Future directions Due to the perception that PPIs are the only treatment for GERD drug development in this field has . . .
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