Novel o-conotoxin gexiva[1,2] nonaddictive analgesic with pharmacokinetic modelling-based mechanistic assessment

HIGHLIGHTS

  • who: Xiaoyu Zhu and colleagues from the Key Laboratory of Tropical Biological Resources, Ministry of Education, Hainan University, Haikou, China have published the research: Novel O-conotoxin GeXIVA[1,2] Nonaddictive Analgesic with Pharmacokinetic Modelling-Based Mechanistic Assessment, in the Journal: Pharmaceutics 2022, 1789 of /2022/
  • what: Modelling and PD for Mechanism a better fit,of implying a lag inon effectiveness Both the rat and dog PK Model simulations suggested that the has effect to link the experiments showed that GeXIVA[1,2] a compartment short half-lifewas in added animals; however, the PK and . . .

     

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