An antagonist for the leukemia inhibitory factor receptor inhibits leukemia inhibitory factor, cardiotrophin-1, ciliary neurotrophic factor, and oncostatin m*

HIGHLIGHTS

  • who: Ann B. Vernallis from the Tufts New England have published the research: An Antagonist for the Leukemia Inhibitory Factor Receptor Inhibits Leukemia Inhibitory Factor, Cardiotrophin-1, Ciliary Neurotrophic Factor, and Oncostatin M*, in the Journal: (JOURNAL) of June/26,/1997
  • what: In the experiment shown, 15 nM hLIF-05 achieved 50% inhibition of hLIF (Fig 1A), compared with 10 nM for 50% inhibition of hOSM (Fig 1B).
  • how: In this study a LIF antagonist that was free of detectable agonistic activity was tested for antagonism against the family of LIF-R ligands . . .

     

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