Enhanced plasmin inhibition by a reactive center lysine mutant of the kunitz-type protease inhibitor domain of the amyloid î²-protein precursor (∗)

HIGHLIGHTS

• who: William E. Van Nostrand from the The Alzheimer's disease related protein, amyloid b-protein precursor (AbPP), contains a domain homologous to Kunitz-type serine protease inhibitors (KPI)The recombinant KPI domain of AbPP is a potent inhibitor of coagulation factors XIa and IXa and functions as an anticoagulant in vitro. Here we report the expression, purification, and characterization of a reactive center lysine mutant of the KPI domain of AbPP (KPILys17). An expression plasmid for the KPI-Lys, domain of AbPP encoded amino acids, of the AbPP cDNA containing a lysine substitution at arginine , in . . .
  

   

  

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