HIGHLIGHTS
- who: Pushkar Sharma from the (UNIVERSITY) have published the paper: Phosphorylation of MEK1 by cdk5/p35 Down-regulates the Mitogen-activated Protein Kinase Pathway*, in the Journal: (JOURNAL) of September/26,/2001
- what: The authors investigated the relationship between cdk5 activity and regulation of the mitogen-activated protein (MAP) kinase pathway. The authors report that cdk5 phosphorylates the MAP kinase kinase-1 (MEK1) in_vivo as well as the Ras-activated MEK1 in_vitro. The model of cdk5/p35 down-regulation of the MAP kinase signaling cascade is shown in Fig 6 on left side of the . . .
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