Genetic engineering and enrichment of human nk cells for car-enhanced immunotherapy of hematological malignancies

HIGHLIGHTS

• who: Maren Soldierer from the Miltenyi Biotec, United States University Children's Hospital have published the research work: Genetic Engineering and Enrichment of Human NK Cells for CAR-Enhanced Immunotherapy of Hematological Malignancies, in the Journal: (JOURNAL)
• what: The authors intended to establish the transduction of primary human NK cells derived from peripheral blood in a feeder-cell-free and CliniMACS Prodigy™-compatible system using the NK MACS medium from Miltenyi Biotec and also addressed several issues in genetic engineering of NK cells, including optimized transgene_expression, alternative lentiviral pseudotypes, and transduction enhancers.
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