Rag gtpases and phosphatidylinositol 3-phosphate mediate recruitment of the ap-5/spg11/spg15 complex

HIGHLIGHTS

• who: Rag GTPases and collaborators from the Institute for Medical Research, University of Cambridge, Cambridge, UK have published the paper: Rag GTPases and phosphatidylinositol 3-phosphate mediate recruitment of the AP-5/SPG11/SPG15 complex, in the Journal: (JOURNAL) of 02/09/2022
• what: The authors show that recruitment of AP-5/SPG11/SPG15 is enhanced in starved cells and occurs by coincidence detection, requiring both phosphatidylinositol 3-phosphate (PI3P) and Rag GTPases. The authors propose that AP-5/SPG11/SPG15 may interact with a binding_site that is unique to RagC but that is only . . .
  

   

  

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