Blood-derived macrophages prone to accumulate lysosomal lipids trigger oxldl-dependent murine hepatic inflammation

HIGHLIGHTS

• who: Tom Houben from the Niemann-Pick type, nih mutant (Npc, ) mice (a kind gift from ProfDr. Lieberman from University of Michigan Medical School) were backcrossed into a C BL/, background for more than , generations. Npc1mut and Ldlr-/- mice were housed under standard conditions and had access to food and water ad libitum. Experiments were performed according to Dutch regulations and approved by the Committee for Animal Welfare of Maastricht University. To generate myeloid Npc, mut deficient Ldlr, mice, bone marrow transplantations were performed. Twenty-two week-old female Ldlr-/- mice received antibiotic water containing neomycin (, mg . . .
  

   

  

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