Double-stranded rna drives sars-cov-2 nucleocapsid protein to undergo phase separation at specific temperatures

HIGHLIGHTS

  • who: Applied Physical, Sciences and Bethesda, from the Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, Lineberger have published the article: Double-stranded RNA drives SARS-CoV-2 nucleocapsid protein to undergo phase separation at specific temperatures, in the Journal: (JOURNAL)
  • what: The authors show that the two RNA-binding domains in Nprotein interact with distinct RNA-sequence and structure elements. The work provides the first evidence of dsRNA/RBD interactions in specifying temperaturesensitive behavior in any phase separating system. The authors show that (i) RBD2 prefers dsRNA in . . .

     

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