HIGHLIGHTS
- who: Groningen and collaborators from the University of Medical Center, Nijmegen, The Netherlands have published the Article: Dominant functional role of the novel phosphorylation site S811 in the human renal NaCl cotransporter, in the Journal: (JOURNAL)
- what: The aim of the current study, therefore, is to investigate the role of S811 phosphorylation in the regulation of NCC by a combination of biochemical and fluorescent microscopy analyses. The authors demonstrate that hypotonic low-chloride buffer increases S811 phosphorylation, whereas phosphorylation-deficient S811A mutant hinders phosphorylation at T55 and T60 in NCCSV and NCC3.
- how . . .
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