Vdup1 deficiency promotes the severity of dss-induced colitis in mice by inducing macrophage infiltration

SUMMARY

    Dysfunctions in intestinal epithelial_cell (IEC) turnover and the goblet cell mucus layer have been associated with the progression of UC. Indeed, macrophages and epithelial_cells isolated from the inflamed intestinal tissues of human UC specimens showed increased levels of NF-κB activation. Conversely, studies have reported that VDUP1 is concurrently being conducted investigate VDUP1 inhibition and protects against various diseases, includingto steatohepatitis, hepatocarcinogenesis, activation in the gastritis, and of gastric carcinogenesis, in animal models. The role of VDUP1 as a promoter treatment diseases. or suppressor of inflammation and inflammation-related disorders is controversial, as it VDUP1 expression is . . .

     

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