A polyamine-based dinitro-naphthalimide conjugate as substrates for polyamine transporters preferentially accumulates in cancer cells and minimizes side effects in vitro and in vivo

HIGHLIGHTS

  • who: Jiajia Wang and collaborators from the University of Florence, Italy have published the research work: A Polyamine-Based Dinitro-Naphthalimide Conjugate as Substrates for Polyamine Transporters Preferentially Accumulates in Cancer Cells and Minimizes Side Effects in vitro and in vivo, in the Journal: (JOURNAL)
  • what: One of the major reasons why amonafide and mitonafide cannot be used widely is because they can have serious side effects in cancer patients. The authors focus on 5c for the following tests. The upregulated PAO is also believed to be among the major reasons for 5c to overcome . . .

     

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