SUMMARY
The landmark work in developing the first monoclonal_antibodies and producing the first FDA-approved antibody, muromonab-CD3 (Orthoclone, OKT3, developed for acute transplant rejection), paved the way for more than 100 therapeutic and diagnostic antibodies. The main indications for monoclonal_antibodies are cancer and autoimmune diseases, collectively making up ~78% of the total antibody sales in the the authors. Murine monoclonal_antibodies, derived from mice and rats of the Muridae family, are IgGs that kicked off the modern development of therapeutic antibodies. Group 3 uses "mig" for multi-immunoglobulins (including bi- and multi-specific monoclonal_antibodies), regardless of the format . . .
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