SUMMARY
Neurodevelopmental disorders (NDDs) are a group of disorders that impact the development and functioning of the brain and exhibit extensive genetic and clinical variability. By utilizing mice with specific mutations in the TRA2B gene in the cortex, the researchers observed that the depletion of Tra2β leads to apoptosis of neural progenitor cells and disruption of the cortical plate. Previously, a group of authors first associated germline variants in the TRA2B gene to a novel neurodevelopmental syndrome. In this study,negative a novelmechanism. de novo variant has been identified in the TRA2B gene in atranslation start site, resulting . . .
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