Alisertib promotes apoptosis and autophagy in melanoma

HIGHLIGHTS

  • who: Top from the Department of Dermatology, General Hospital of NingXia Medical University, Yinchuan, PRChina have published the Article: Alisertib promotes apoptosis and autophagy in melanoma, in the Journal: (JOURNAL)
  • how: These results indicated that ALS induced autophagy in both A375 and skmel-5 cells. The authors investigated the role of AURKA in tumorigenesis in a mouse model of melanoma.
  • future: Studies are required to elucidate the role of p38 MAPK in chemotherapy-induced autophagy.

SUMMARY

    The p38 MAPKs regulate cell growth, cell cycle progression, apoptosis, and autophagy. The . . .

     

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