Inflammation and nf-b signaling in prostate cancer: mechanisms and clinical implications

HIGHLIGHTS

• who: Jens Staal and Rudi Beyaert from the Department of Biomedical Molecular Biology, University, have published the paper: Inflammation and NF-B Signaling in Prostate Cancer: Mechanisms and Clinical Implications, in the Journal: (JOURNAL)
• what: Androgen deprivation therapy has become the main prostate cancer therapy for patients at different stages of disease.

SUMMARY

IKKε is a downstream target that is induced by NF-κB and inhibited by AR in prostate cancer cells, and AR-negative prostate cancer cells show constitutive IKKε activation. IL-30 (IL-27 p28 form) expression from prostate . . .

 



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