Evidence for an extended hydrogen bond network in the binding site of the nicotinic receptor

HIGHLIGHTS

• who: Angela P. Blum from the (UNIVERSITY) have published the article: Evidence for an Extended Hydrogen Bond Network in the Binding Site of the Nicotinic Receptor, in the Journal: (JOURNAL) of September/16,/2011
• what: The work has emphasized the gauche(⫺) as this is the conformation seen in AChBP crystal_structures. The authors chose to focus on the muscle subtype for the following reasons.

SUMMARY

The authors use subtle structural variations enabled by unnatural amino_acid mutagenesis to evaluate the possible functional role of the vicinal disulfide of nAChR ␣ subunits. This hydrogen_bond is . . .

 



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