Inactivation of human manganese-superoxide dismutase by peroxynitrite is caused by exclusive nitration of tyrosine 34 to 3-nitrotyrosine*

HIGHLIGHTS

• who: Fumiyuki Yamakura from the (UNIVERSITY) have published the research work: Inactivation of Human Manganese-superoxide Dismutase by Peroxynitrite Is Caused by Exclusive Nitration of Tyrosine 34 to 3-Nitrotyrosine*, in the Journal: (JOURNAL) of February/20,/1998
• what: This study proposes that nitration of a specific tyrosine residue is responsible for inactivation of recombinant human mitochondrial manganese-superoxide dismutase (Mn-SOD) by peroxynitrite.
• how: For this structural analysis study the authors used 11.8 mM Mn-SOD and 1 mM peroxynitrite at pH 7.4.
• future: Study is required to . . .
  

   

  

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