Parp14 is a novel target in stat6 mutant follicular lymphoma

HIGHLIGHTS

  • who: Michael Mentz from the (UNIVERSITY) have published the article: PARP14 is a novel target in STAT6 mutant follicular lymphoma, in the Journal: (JOURNAL) of 18/07/2022
  • what: Conceptually, the authors propose that this IL-4 driven re-education process of the TME is composed of at least two self-reinforcing regulatory circuits, an intracellular and an extracellular route (Fig 6). The authors focused on the molecular mechanisms of the intracellular route (the microcircuit) and identified several aspects of clinical-translational relevance. In fact, the authors show that pharmacological inhibition of the PARP enzymatic . . .

     

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