HIGHLIGHTS
- who: Lea Beltzig and collaborators from the Institute of Neuropathology, University Medical Center, Mainz, Germany have published the research: Senescence Is the Main Trait Induced by Temozolomide in Glioblastoma Cells, in the Journal: Cancers 2021, x of 17/03/2022
- what: The authors show that TMZ-induced CSEN is a late response which has similar kinetics to apoptosis but at a fourfold higher level. Using a Tet-On glioblastoma cell system the authors show that upregulation of immediately after TMZ completely abrogated apoptosis and CSEN while induction of long-term (>72 h) after TMZ did . . .
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