The critical role of hypoxia in the re-differentiation of human articular chondrocytes

HIGHLIGHTS

  • who: Carlos Martinez-Armenta and colleagues from the Graduate Program in Experimental Biology, DCBS, Universidad Autónoma Metropolitana Iztapalapa, Mexico City, Mexico have published the paper: The Critical Role of Hypoxia in the Re-Differentiation of Human Articular Chondrocytes, in the Journal: Cells 2022, 11, 2553. of /2022/
  • what: To address this problem the authors develop a 3D culture system generating scaffold-free spheroids from human chondrocytes. This study shows the influence of 3D culture conditions combined with hypoxia maintaining the expression of chondrogenic genes and native tissue features in chondrocytes derived from human samples . . .

     

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