The 46.1 antibody mediates neurotensin uptake into the cns and the effects depend on the route of intravenous administration

HIGHLIGHTS

• who: Julia V. Georgieva and collaborators from the Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, WI, USA have published the article: The 46.1 Antibody Mediates Neurotensin Uptake into the CNS and the Effects Depend on the Route of Intravenous Administration, in the Journal: Pharmaceutics 2022, 1706 of /2022/
• what: The authors demonstrate that intravenously administered 46.1-scFv-Fc-LL-NT can elicit transient hypothermia and reduce drug-induced hyperlocomotion confirming that 46.1 can deliver drug cargo to the CNS at pharmacologically relevant doses. For instance, in this study . . .
  

   

  

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