Self-dna release and sting-dependent sensing drives inflammation to cigarette smoke in mice

HIGHLIGHTS

  • who: Mamp#x000E9 and gane Nascimento from the University of Orleans and CNRS, INEM-UMR7355, Orleans, France have published the paper: Self-DNA release and STING-dependent sensing drives inflammation to cigarette smoke in mice, in the Journal: Scientific Reports Scientific Reports of 19/05/2019
  • what: The authors demonstrate that acute exposure to cigarette smoke causes respiratory barrier damage with the release of self-dsDNA in mice. The authors report a critical role of the cGAS/STING/type I interferon pathway in cigarette smoke-induced lung inflammation. The authors show that mouse CS-exposure . . .

     

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