HIGHLIGHTS
- who: Diana M. Mitrea from the Centrosome have published the article: Modulating biomolecular condensates: a novel approach to drug discovery, in the Journal: (JOURNAL)
- what: In this Perspective, the authors propose that such insights could enable a previously unexplored drug discovery approach based on identifying condensate-modifying therapeutics (c-mods), and the authors discuss the strategies, techniques and challenges involved. This approach has been used to identify hits that inhibit stress-induced aggregation of TDP43 (ref187), stress granule formation31,32 and p53-Mdm2 interaction188. How do the authors demonstrate causality between disease and condensatopathies? A . . .
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