Gpt2 is induced by hypoxia-inducible factor (hif)-2 and promotes glioblastoma growth

HIGHLIGHTS

• who: Bo Zhang and collaborators from the Department of Pathology, UT Southwestern Medical Center, Dallas, TX, USA have published the article: GPT2 Is Induced by Hypoxia-Inducible Factor (HIF)-2 and Promotes Glioblastoma Growth, in the Journal: Cells 2022, x of /2022/
• what: The authors report that GPT2 is directly induced by HIF-2 in human GBM. The authors show here that GPT2 is localized in the nucleus, in addition to mitochondria.
• future: Whether or not GPT2 regulates HIF-mediated alterations in glutamate and glutamine metabolism leading to GBM progression requires future investigation . . .
  

   

  

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