Transcription-independent regulation of sting activation and innate immune responses by irf8 in monocytes

HIGHLIGHTS

• who: Wei-Wei Luo from the Reagents, antibodies, viruses and cells LMW-Poly(I:C), LPS, ′3′-cGAMP and DMXAA (InvivoGen) have published the paper: Transcription-independent regulation of STING activation and innate immune responses by IRF8 in monocytes, in the Journal: (JOURNAL) of 26/07/2022
• what: The authors show that interferon regulatory factor 8 (IRF8) is essential for efficient activation of STINGmediated innate immune_responses in monocytes. In light of these results and previous studies on the mechanisms of Sting-mediated Irf3 activation, the authors propose a working model on how Irf8 modulates innate . . .
  

   

  

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