Natural variants of human sarm1 cause both intrinsic and dominant loss-of-function influencing axon survival

HIGHLIGHTS

• who: Mirlinda Ademi from the DepartmentUniversity of have published the research: Natural variants of human SARM1 cause both intrinsic and dominant loss-of-function influencing axon survival, in the Journal: Scientific Reports Scientific Reports
• what: The authors purposefully injected small amounts of SARM1 expression constructs in these assays to avoid excessive overexpression and the authors propose that this cytotoxicity might reflect an interaction between a moderate, acute increase in NADase activity in neurons previously lacking SARM1 and the stresses associated with injection. A false discovery rate (FDR) correction was applied to multiple comparisons in all . . .
  

   

  

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