Mitochondrial calpain-1 activates nlrp3 inflammasome by cleaving atp5a1 and inducing mitochondrial ros in cvb3-induced myocarditis

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  • who: Xiaoxiao Liu from the Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Shanghai Medical College of Fudan University, Shanghai, China have published the Article: Mitochondrial calpain-1 activates NLRP3 inflammasome by cleaving ATP5A1 and inducing mitochondrial ROS in CVB3-induced myocarditis, in the Journal: (JOURNAL)
  • what: The authors aimed to unveil the regulatory mechanism of calpain in the development of CVB3-induced myocarditis and explore the specific target of calpain, which may offer insights into novel cardioprotective therapeutic approaches for myocarditis treatment. The authors demonstrated that calpain inhibition in_vivo and in_vitro alleviated . . .

     

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