Changes in physicochemical and anticancer properties modulated by chemically modified sugar moieties within sequence-related g-quadruplex structures

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  • who: Carolina Roxo and Anna Pasternak from the Department of Nucleic Acids Bioengineering, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland have published the Article: Changes in physicochemical and anticancer properties modulated by chemically modified sugar moieties within sequence-related G-quadruplex structures, in the Journal: PLOS ONE of June/23,/2022
  • what: The studies show that the influence of each modification on the physicochemical properties of G-quadruplexes is position-dependent due to mutual interactions between G-tetrads loops and additional guanosine at 5' or 3' end. In this study, the structural . . .

     

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