Inhibition of p2x7 receptors by lu af27139 diminishes colonic hypersensitivity and cns prostanoid levels in a rat model of visceral pain

HIGHLIGHTS

• who: CNS et al. from the (UNIVERSITY) have published the research work: Inhibition of P2X7 receptors by Lu AF27139 diminishes colonic hypersensitivity and CNS prostanoid levels in a rat model of visceral pain, in the Journal: (JOURNAL) of January/30,/2013
• what: In the current study, administration of Lu AF27139 in doses ranging from 30-300 mg/kg was shown to have no significant effect on motor function and coordination when compared to vehicle treatment when assessed either as time to fall from the rotarod (Fig 3a) or rotarod speed (Fig 3b).
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