Mycobacterial resistance to zinc poisoning requires assembly of p-atpase-containing membrane metal efflux platforms

HIGHLIGHTS

• who: Yves-Marie Boudehen from the (UNIVERSITY) have published the Article: Mycobacterial resistance to zinc poisoning requires assembly of P-ATPase-containing membrane metal efflux platforms, in the Journal: (JOURNAL) of 18/07/2022
• what: The authors show that zinc resistance also depends on a chaperone-like protein, PacL1 (Rv3269). This study reveals that the DUF1490 protein PacL1 is necessary for mycobacterial resistance to excess zinc, and plays an unexpected dual role: 1) The authors propose that PacL1 stabilizes and promotes membrane incorporation of CtpC in metal efflux platforms.
• how: All real-time . . .
  

   

  

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