Cox2 regulates senescence secretome composition and senescence surveillance through pge2

HIGHLIGHTS

  • who: Susana Gonçalves from the CR UKUniversity of have published the Article: COX2 regulates senescence secretome composition and senescence surveillance through PGE2, in the Journal: (JOURNAL) of March/16,/2021
  • what: The authors show that RAS-induced (RIS) is a critical regulator of SASP composition and surveillance vivo. regulates the expression of multiple inflammatory SASP components through an autocrine feedback loop involving its downstream product prostaglandin E2 (PGE2) binding to EP4. vivo RIS is critical to tumor suppression Cxcl1 expression and immune-mediated surveillance partially through PGE2.
  • how: To study which receptor . . .

     

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