Roquin targets mrnas in a 3⠲-utr-specific manner by different modes of regulation

HIGHLIGHTS

• who: Katharina Essig from the Institute University of , München, Germany have published the research work: Roquin targets mRNAs in a 3⠲-UTR-specific manner by different modes of regulation, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: Through mRNA-seq and ribosome footprinting analyses the authors provide evidence that the majority of Roquin targets is regulated by decay, whereas a smaller set of targets, whose 3′UTRs contain more Roquin binding_sites, is additionally repressed through translational inhibition. To support this analysis the authors investigated the regulation of two targets-Sgk1 and Nfat5-harboring 3 . . .
  

   

  

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