A novel inhibitor of plasmodium falciparum spermidine synthase: a twist in the tail

HIGHLIGHTS

  • who: Pieter B Burger from the Department of Biochemistry, UP Centre for Sustainable Malaria Control, Faculty of Natural and Agricultural Sciences, University of Pretoria, Private Bag, Hatfield, South Africa have published the Article: A novel inhibitor of Plasmodium falciparum spermidine synthase: a twist in the tail, in the Journal: (JOURNAL)
  • what: In this study however, compound 9 was identified as a PfSpdS inhibitor with an IC50 comparable to the most potent known inhibitors of PfSpdS.
  • how: The HYD features were identified using both the DRY (a general hydrophobic probe) and Me (the C3 . . .

     

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