Kshv induces immunoglobulin rearrangements in mature b lymphocytes

HIGHLIGHTS

• who: Jennifer Totonchy and colleagues from the Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Irvine, CA, United have published the research: KSHV induces immunoglobulin rearrangements in mature B lymphocytes, in the Journal: (JOURNAL) of April/16,/2018
• what: The authors show that this phenotypic shift occurs via re-induction of Rag-mediated V(D)J recombination. The authors develop a novel system for infecting B cells from human tonsil with and tracking how the virus alters the cells over time. Using this system the authors demonstrate a number of KSHV-driven alterations in . . .
  

   

  

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