Functional annotation of the 2q35 breast cancer risk locus implicates a structural variant in influencing activity of a long-range enhancer element

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  • who: Joseph S. Baxter from the The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London , RP, UK have published the research: Functional annotation of the 2q35 breast cancer risk locus implicates a structural variant in influencing activity of a long-range enhancer element, in the Journal: (JOURNAL) of June/18,/2021
  • what: The authors propose a model in which the deletion allele of esv3594306 juxtaposes two transcription factor binding regions (annotated by estrogen receptor alpha ChIP-seq peaks) to generate a single extended regulatory element. In this analysis the authors . . .

     

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