Transient receptor potential channel 6 knockdown prevents apoptosis of renal tubular epithelial cells upon oxidative stress via autophagy activation

HIGHLIGHTS

• who: Xin Hou from the TRPC6-deficient (TRPC6-/-) mice on a SvEv background were generated at the Comparative Medicine Branch (CMB) of the National Institute of Environmental Health Sciences (NIEHS), North Carolina, USA WT SvEv mice were also introduced from NIEHS and served as controls for the KO mice. Age-matched male KO and WT controls were used for all studies. Animals were treated in compliance with the Guide for the Care and Use of Laboratory Animals (National Academy of Science). Animals were kept on a, h light-dark cycle in a temperature-controlled room with ad . . .
  

   

  

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