Critical role of the hdac6-cortactin axis in human megakaryocyte maturation leading to a proplatelet-formation defect

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  • who: Kahia Messaoudi from the National de la Santé et de la Recherche Médicale, UMR, Equipe labellisée par la Ligue Nationale contre le Cancer, Villejuif, France have published the article: Critical role of the HDAC6-cortactin axis in human megakaryocyte maturation leading to a proplatelet-formation defect, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
  • what: The authors show that while WT-HDAC6 was mainly cytoplasmic, MUT-HDAC6 was redistributed in MK nuclei, confirming that NES sequences play a central role in the cytoplasmic retention of human HDAC6 (Fig 5b). The authors show that . . .

     

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