Rho-kinase inhibitor y-27632 and hypoxia synergistically enhance chondrocytic phenotype and modify s100 protein profiles in human chondrosarcoma cells

HIGHLIGHTS

• who: Juha Piltti from the Department of Integrative Medical Biology, Umeå University, Linnaeus väg, Umeå, Sweden have published the article: Rho-kinase inhibitor Y-27632 and hypoxia synergistically enhance chondrocytic phenotype and modify S100 protein profiles in human chondrosarcoma cells, in the Journal: Scientific Reports Scientific Reports of 25/Nov/2016
• what: The authors show that inhibition by Y-27632 under hypoxic conditions efficiently maintains and even enhances chondrocyte-specific extracellular matrix production by chondrocytic cells. The aim of this study was to investigate a way to enhance the expression of the major cartilage . . .
  

   

  

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