Developmental programming of cardiovascular dysfunction by prenatal hypoxia and oxidative stress

HIGHLIGHTS

  • who: Dino A. Giussani et al. from the Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom have published the article: Developmental Programming of Cardiovascular Dysfunction by Prenatal Hypoxia and Oxidative Stress, in the Journal: (JOURNAL) of February/13,/2012
  • what: The authors show that maternal treatment with antioxidants during pregnancy can restore this programmed impaired vasodilator phenotype in adult offspring, providing new evidence for the mechanism mediating the developmental programming of endothelial dysfunction by prenatal chronic hypoxia to be due to vascular oxidative stress. The authors show that chronic prenatal hypoxia . . .

     

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