HIGHLIGHTS
- who: Mohammad Amin Moosavi and Mojgan Djavaheri-Mergny from the Department of Molecular Medicine, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran have published the Article: Autophagy: New Insights into Mechanisms of Action and Resistance of Treatment in Acute Promyelocytic leukemia, in the Journal: (JOURNAL)
- what: While autophagy is downregulated in APL cells, this process can be activated in response to ATRA and ATO, two agents currently used in clinical settings.
SUMMARY
Indeed, inhibition of neddylation by MLN4924 (a small_molecule that specifically blocks the activity of NEDD8 E1-activating enzyme . . .
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