Inhibition of ire1 rnase activity modulates the tumor cell secretome and enhances response to chemotherapy

HIGHLIGHTS

• who: Susan E. Logue from the National University have published the paper: Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors evaluate the outcome of blocking IRE1 RNase activity in triple-negative breast cancer (TNBC) cells using a small_molecule inhibitor-MKC8866. Using this approach the authors observed reduced levels of IL-6, IL-8, GM-CSF, and CXCL1 in MKC8866 conditioned medium compared to vehicle-only conditioned medium (TGFβ2 was not present on the array) (Fig 4a). The . . .
  

   

  

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