Dynamic regulatory on/off minimization for biological systems under internal temporal perturbations

HIGHLIGHTS

  • who: Sabrina, Kleessen and Zoran, Nikoloski from the (UNIVERSITY) have published the research: Dynamic regulatory on/off minimization for biological systems under internal temporal perturbations, in the Journal: (JOURNAL)
  • what: The authors propose a suite of novel methods for analyzing the dynamics of_(internally perturbed) metabolic networks and for quantifying their robustness with limited knowledge of kinetic parameters. By conducting a comparative analysis with a kinetic model of the Calvin-Benson cycle and a model of plant carbohydrate metabolism the authors demonstrate that the principle of regulatory on/off minimization coupled with dynamic FBA can . . .

     

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