HIGHLIGHTS
- who: Nagarajan Elumalai from the Institute of Organic Chemistry, Leipzig University, Johannisallee, Leipzig, Germany Institute of have published the Article: Rational development of Stafib-2: a selective, nanomolar inhibitor of the transcription factor STAT5b, in the Journal: Scientific Reports Scientific Reports of 10/03/2017
- what: The authors demonstrate STAT5b binding of catechol bisphosphate by solid-state nuclear magnetic resonance and report on rational optimization of Stafib-1 (Ki = 44 nM) to Stafib-2 (Ki = 9 nM). The authors propose Pomstafib-2 which currently represents the most active selective inhibitor of STAT5b activation available as . . .
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