Icos coreceptor signaling inactivates the transcription factor foxo1 to promote tfh cell differentiation

HIGHLIGHTS

• who: Erica L. Stone from the Department University of CA, USA have published the research work: ICOS Coreceptor Signaling Inactivates the Transcription Factor FOXO1 to Promote Tfh Cell Differentiation, in the Journal: (JOURNAL) of February/17,/2015
• what: The authors report that ICOS signaling inactivates the transcription factor FOXO1 and a Foxo1 genetic deletion allowed for generation of Tfh cells with reduced dependence on ICOS ligand. The authors propose that ICOS signaling transiently inactivates FOXO1 to initiate a Tfh cell contingency that is completed a FOXO1-dependent manner. To account for the increase in activated . . .
  

   

  

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